Stroke Death After Lovenox Discontinued: $6.6 Million Verdict

Q: Does stroke severity predict hemorrhagic transformation?

Stroke severity is a strong predictor for hemorrhagic transformation and could be a possible explanation for the absence of bleeding in patients in whom anticoagulation was continued (indication bias). 10 Last, the results are not applicable to patients with AIS and a concurrent infection at baseline, because these patients were excluded from PASS.

Q: Does anticoagulation affect mortality and clinical outcomes at 90 days?

Mortality and clinical outcomes at 90 days were worse in patients in whom anticoagulation was discontinued (mortality, 31% versus 15%; P =0.019 and modified Rankin Scale score of 0–2, 20% versus 55%; P <0.001). After adjustment for potential confounders, there were no statistically significant differences between groups.

Q: What happens If anticoagulation is discontinued?

There were no major bleeding events in either group. Mortality and clinical outcomes at 90 days were worse in patients in whom anticoagulation was discontinued (mortality, 31% versus 15%; P =0.019 and modified Rankin Scale score of 0–2, 20% versus 55%; P <0.001).

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FAQs about Stroke Death After Lovenox Discontinued: $6.6 Million Verdict Coupon?

Does anticoagulation stop after a stroke?

Among patients with a severe stroke (NIHSS>15), anticoagulation was stopped in 14/27 (52%) patients, compared with 21/165 (13%) of those with mild or moderate deficits (NIHSS≤15; P <0.001). Table 1. Baseline Characteristics ...

Does stroke severity predict hemorrhagic transformation?

Stroke severity is a strong predictor for hemorrhagic transformation and could be a possible explanation for the absence of bleeding in patients in whom anticoagulation was continued (indication bias). 10 Last, the results are not applicable to patients with AIS and a concurrent infection at baseline, because these patients were excluded from PASS. ...

Does anticoagulation affect mortality and clinical outcomes at 90 days?

Mortality and clinical outcomes at 90 days were worse in patients in whom anticoagulation was discontinued (mortality, 31% versus 15%; P =0.019 and modified Rankin Scale score of 0–2, 20% versus 55%; P <0.001). After adjustment for potential confounders, there were no statistically significant differences between groups. ...

What happens If anticoagulation is discontinued?

There were no major bleeding events in either group. Mortality and clinical outcomes at 90 days were worse in patients in whom anticoagulation was discontinued (mortality, 31% versus 15%; P =0.019 and modified Rankin Scale score of 0–2, 20% versus 55%; P <0.001). ...