Daytime DNase-I Administration Protects Mice From Ischemic …

Jan 27, 2025 · BACKGROUND: Acute ischemic stroke treatment typically involves tissue-type plasminogen activator (tPA) or tenecteplase, but about 50% of patients do not achieve …

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Daytime DNase-I Administration Protects Mice From Ischemic …

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Jan 27, 2025 · BACKGROUND: Acute ischemic stroke treatment typically involves tissue-type plasminogen activator (tPA) or tenecteplase, but about 50% of patients do not achieve …

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Daytime DNase-I Administration Protects Mice From Ischemic …

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Acute ischemic stroke treatment typically involves tissue-type plasminogen activator (tPA) or tenecteplase, but about 50% of patients do not achieve successful reperfusion. The causes of …

nih.gov

FAQs about Daytime DNase-I Administration Protects Mice From Ischemic … Coupon?

Can dnase-1 be used to treat ischemia & reperfusion?

It is our hope that more evidence-based therapeutic options will become available in the near future. Our research focus on exploring the effect of short time administration of DNAse-1 on rats after 1 h of ischemia and 2 h of reperfusion. However, the long-term outcome of DNase-1 treatment remains obscure. ...

Does dnase-1 affect long-term outcome after ischemia and reperfusion?

Our research focus on exploring the effect of short time administration of DNAse-1 on rats after 1 h of ischemia and 2 h of reperfusion. However, the long-term outcome of DNase-1 treatment remains obscure. Moreover, the influence of DNAse-1 on intestine subjected to different reperfusion times after injury by 1 h ischemia is unknown. ...

Can dnase-1 protect the intestine from injury?

The successful clearance of NETs in an in vivo study showed that DNase-1 can attenuate acute kidney, hepatic and myocardial I/R injury 16, 18, 23. Recently, we reported that NETs contribute to intestinal damage in endotoxemic rats and that treatment with DNase-1 may protect the intestine from injury 21. ...

Is dnase-1 an effective treatment for I/r-challenged intestinal tissues?

Our results indicate the existence of NETs in I/R-challenged intestinal tissues and firstly provide more evidence that DNase-1 may be an effective treatment for attenuating intestinal I/R injury. ...

What is the long-term outcome of dnase-1 treatment?

However, the long-term outcome of DNase-1 treatment remains obscure. Moreover, the influence of DNAse-1 on intestine subjected to different reperfusion times after injury by 1 h ischemia is unknown. It would be very interesting to understand these issues in future work. ...

Is dnase-1 effective during I/r injury and sepsis?

Indeed, high levels of cfDNA have been observed in the blood during I/R, inflammation, coagulation and sepsis 13, 16, 21, and the administration of DNase-1 is reportedly effective during I/R injury and sepsis 16, 18, 22. ...