Varenicline for smoking cessation: a narrative review of efficacy ...

Both varenicline and cytisine target the α4β2 receptor. 20, 21 In vitro and in vivo animal studies found that cytisine has a lower affinity for the α4β2 compared to its affinity to other nAChR …

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FAQs about Varenicline for smoking cessation: a narrative review of efficacy ... Coupon?

Does varenicline increase smoking cessation rates?

Varenicline, with its unique profile of agonist and antagonist properties, increased cessation rates (both short- and long-term) compared with both placebo and bupropion sustained release. Keywords: nicotinic receptors; review; smoking cessation; varenicline. ...

Is varenicline effective?

Conclusions: Varenicline is efficacious and safe for all adult smokers with a range of clinical characteristics. Evidence suggests that approaches offering greater flexibility in timing and duration of treatment may further extend treatment efficacy and clinical reach. Keywords: Efficacy; pharmacotherapy; safety; smoking cessation; varenicline. ...

Is varenicline a good treatment for smoking relapse?

Varenicline is the most recent addition to the pharmacotherapeutic armamentarium for the treatment of tobacco dependence. Varenicline is efficacious and cost-effective. Smoking relapse and adverse treatment-related side effects may decrease medication adherence and patient satisfaction with varenicline. ...

How can varenicline treatment be optimized?

In the clinical setting, varenicline treatment can be optimized by reducing doses in patients who experience intolerable side effects, increasing the dose in partial responders, and providing long-term maintenance therapy for relapse prevention. Keywords: varenicline, tobacco dependence, smoking cessation, nicotine addiction ...

Do varenicline and cytisine increase quit rates?

A recent Cochrane review has demonstrated high-certainty evidence that varenicline and cytisine increase quit rates . Another current and controversial smoking cessation aid, categorized as a harm reduction strategy, is the use of electronic nicotine delivery systems (ENDS). ...

Is varenicline a nicotinic ligand?

Background: Smoking is the leading preventable risk to human health. Various agents have been used to promote smoking cessation, but none has had long-term efficacy. Varenicline, a new nicotinic ligand based on the structure of cytosine, was approved by the US Food amd Drug Administration for use as a smoking cessation aid. ...